2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040256
    Acid phosphatase, wheat 9001-77-8
    Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions.
    Acid phosphatase, wheat
  • HY-W062542
    1-Methylhistamine 501-75-7 99.83%
    1-Methylhistamine is a histamine (Him) metabolite.
    1-Methylhistamine
  • HY-W067056
    Methyl (E)-cinnamate 1754-62-7 99.87%
    Methyl (E)-cinnamate (Methyl (E)-3-phenylpropenoate) is a natural flavor compound with anti-inflammatory properties found in Alpinia katsumadai Hayata. Methyl (E)-cinnamate induces apoptosis via reduced anti-apoptotic protein expression, increased TUNEL-positive cells, and apoptotic morphological changes. Methyl (E)-cinnamate can be used for the research of abnormalities of osteoblast function in bone diseases.
    Methyl (E)-cinnamate
  • HY-W096159
    D-Biotinol 53906-36-8
    D-Biotinol is an orally active alcohol analogue of D-Biotin (HY-B0511). D-Biotinol can replace D-Biotin to restore the biotin deficiency induced by egg whites in rats. D-Biotinol can be used for the study of biotin deficiency disorders.
    D-Biotinol
  • HY-W653982
    Coproporphyrin I-15N4 99.19%
    Coproporphyrin I-15N4 is a 15N-labeled Coproporphyrin I (HY-113318). Coproporphyrin I is an endogenous metabolite present in urine and blood that can be used for the research of liver disease and porphyria.
    Coproporphyrin I-15N4
  • HY-111614S2
    Melengestrol acetate-d3 99.0%
    Melengestrol acetate-d3 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate-d3
  • HY-125818S3
    Cytidine-5'-triphosphate-13C9 dilithium 98.02%
    Cytidine-5'-triphosphate-13C9 (Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-13C9 dilithium
  • HY-N0229S10
    L-Alanine-13C3,15N 202407-38-3 98.0%
    L-Alanine-13C3,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C3,15N
  • HY-W009216R
    2'-Deoxycytidine-5'-monophosphate (Standard) 1032-65-1 99.60%
    2'-Deoxycytidine-5'-monophosphoric acid (Standard) is the analytical standard of 2'-Deoxycytidine-5'-monophosphoric acid. This product is intended for research and analytical applications. 2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite. 2'-Deoxycytidine-5'-monophosphate is a deoxynucleotide building block of which DNA is made. 2'-Deoxycytidine-5'-monophosphate can be used as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP and supports DNA biosynthesis.
    2'-Deoxycytidine-5'-monophosphate (Standard)
  • HY-W010382S
    Oxaloacetic acid-13C4 161096-82-8 ≥98.0%
    Oxaloacetic acid-13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis.
    Oxaloacetic acid-13C4
  • HY-W011690S
    L-Homocystine-d8 182755-41-5 99.94%
    L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
    L-Homocystine-d8
  • HY-W012734R
    L-Pipecolic acid (Standard) 3105-95-1 99.91%
    L-Pipecolic acid (Standard) is an analytical standard of L-Pipecolic acid. This product is used for research and analytical applications. L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.
    L-Pipecolic acid (Standard)
  • HY-W012980S
    Isovaleric acid-d9 344298-81-3 ≥98.0%
    Isovaleric acid-d9 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
    Isovaleric acid-d9
  • HY-W017007S
    3-Methyl-L-histidine-d3 144868-18-8 99.9%
    3-Methyl-L-histidine-d3 is the deuterium labeled 3-Methyl-L-histidine. 3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin.
    3-Methyl-L-histidine-d3
  • HY-W010042S3
    L-Glucose-13C6 99.43%
    L-Glucose-13C6 (L-(-)-Glucose-13C6) is C13-labeled L-Glucose. L-Glucose is an enantiomer of D-glucose. L-Glucose enhances food intake.
    L-Glucose-13C6
  • HY-43466
    Methyl desoxycholate 3245-38-3 ≥98.0%
    Methyl desoxycholate is an ester product.
    Methyl desoxycholate
  • HY-P3003
    Cereulide 157232-64-9
    Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
    Cereulide
  • HY-P3185
    beta-Galactose dehydrogenase 9028-54-0
    Beta-galactose dehydrogenase is a selective catalyst for β-galactose. Under pH 8.6 conditions, beta-galactose dehydrogenase catalyzes the oxidation of β-galactose, produced by the hydrolysis of lactose by β-galactosidase, with nicotinamide adenine dinucleotide (NAD) to produce reduced nicotinamide adenine dinucleotide (NADH). Beta-galactose dehydrogenase specifically mediates this oxidation reaction for the quantitative detection of the substrate, used in the analysis of lactose concentration in samples such as breast milk.
    beta-Galactose dehydrogenase
  • HY-P5489
    IGRP(206-214) 849069-99-4
    IGRP(206-214) is a biological active peptide. IGRP(206-214) corresponds to residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). IGRP(206-214) is T cells specific for proinsulin and IGRP induces diabetes in non-obese diabetic (NOD) mice.
    IGRP(206-214)
  • HY-101998
    CTP inhibitor 412940-35-3 98.00%
    CTP inhibitor (Compound 792949) is a potent and selective CTP inhibitor. CTP inhibitor inhibits the plasma membrane citrate transporter (PMCT).
    CTP inhibitor
Cat. No. Product Name / Synonyms Application Reactivity